Items in this pool can be found in the 
Devil Room.
To see the Devil Room pool of items in the original game, see its page on The Binding of Isaac: Rebirth wiki.
Active Items
| Name
|
Icon
|
Weight
|
Description
|
| Book of Genesis
|
|
1
|
- On use, grants a Black Heart.
- Passively doubles all damage taken.
|
| Lily
|
|
1
|
- On use, explodes any enemies with less than 1/3 of their maximum health remaining.
- Does not work on bosses.
- Valid enemies will faintly glow red.
|
| Bygone Arm
|
|
1
|
- On use, swings an arm, in a similar fashion to Forgotten's bone club.
- The arm can reflect enemy projectiles and, with tighter timing, boost Isaac's own tears.
- Reflected projectiles and boosted tears explode on contact with enemies or obstacles.
- Can be used from any item slot by pressing the button tied to consuming cards and pills, so long as Isaac has no consumable that would otherwise be used.
|
Passive Items
| Name
|
Icon
|
Weight
|
Description
|
| Azazel's Horn
|
|
1
|
- +1 Black Heart.
- Black Hearts will now trigger their mass room damage effect when only partially depleted by damage.
|
| Eve's Nail Polish
|
|
1
|
- Landing a tear on an enemy reduces the time until Isaac can fire his next shot.
|
| Guppy's Pride
|
|
1
|
- Grants a shooting familiar on pickup and at the start of every new floor.
- The familiars' tear damage scales with Isaac's Damage.
|
| Joyful
|
|
1
|
- Grants a chance to gain a 2× damage multiplier for the room when taking damage.
- In the following room afterwards, grants a 0.85× damage multiplier.
- 35% chance for a Joy Pill to drop on room clear, alongside normal rewards.
|
| Slick Spade
|
|
1
|
{{{description}}}
|
| Carapace
|
|
1
|
- Upon entering an uncleared room, Isaac gains a shell that gives the following:
- +1 flat damage.
- 0.75× speed multiplier.
- Negates the first instance of damage, destroying the shell and removing the stat modifiers.
|
| Eye of Balor
|
|
1
|
- The enemy with the lowest percentage health, that is not at full health, will take 1.5x damage from all sources.
|
| Glioma
|
|
1
|
- +0.3 Tears.
- Grants a 15% chance to fire a concussive tear.
- Upon defeating the floor's boss, all regular cleared rooms become uncompleted and can be re-beaten for additional rewards.
|
| Devil's Tooth
|
|
1
|
- Grants a chance to fire a tear that upgrades the hit enemy into a stronger version of itself.
- If the enemy is successfully transformed, its current health is halved.
- Chance scales with Luck.
|
| Heartbroker
|
|
1
|
- +1 Gold Heart.
- +2 Broken Hearts.
- Broken Hearts can now be used to purchase Devil Deals.
|
| Gloriosa
|
|
1
|
- 0.75× tear rate multiplier.
- Tears travel in an arc and leave behind a fire jet when colliding.
- Tears inflict burn to enemies on direct hits.
|
| Kapala
|
|
1
|
- 1.5x Damage Multiplier.
- Damage dealt to enemies is split evenly amongst all other enemies of the same Type and Variant.
|
| Blood of Satan
|
|
1
|
|
Treasure Room
Boss
Shop
Curse Room
Secret Room
Angel Room
Library
Golden Chest
Red Chest
Beggar
Devil Beggar
Key Master
Bomb Bum
Planetarium
Ultra Secret Room
Crane Game
Rotten Beggar
Battery Bum
Old Chest
Wooden Chest
Baby Shop
Swine Beggar
Demon Swine
Angel Swine
Gashapon
Bone Saw
Bougie Pedestal
