Curse Room (Item Pool)

Item Pools
Normal / Hard	Treasure Room	Boss	Shop	Curse Room	Secret Room	Devil Room	Angel Room
	Library	Golden Chest	Red Chest	Beggar	Devil Beggar	Key Master	Bomb Bum
	Planetarium	Ultra Secret Room	Crane Game	Rotten Beggar	Battery Bum	Old Chest	Wooden Chest
	Baby Shop	Swine Beggar	Demon Swine	Angel Swine	Gashapon	Bone Saw	Bougie Pedestal
Greed / Greedier	Treasure Room	Boss	Shop	Curse Room	Secret Room	Devil Room	Angel Room

Items in this pool can spawn in the Curse Room. This does not apply to Red Chests.

To see the Curse Room pool of items in the original game, see its page on The Binding of Isaac: Rebirth wiki.

Active Items

Name	Icon	Weight	Description
Black Box		1	+4 luck while held. Each use: −0.5 luck permanently. Chance to spawn an item, Black Heart, Card, or hostile Spiders based on luck.
Book of Genesis		1	On use, grants a Black Heart. Passively doubles all damage taken.
Death Cap		1	When using for the first 5 times, Isaac takes damage and permanently gains the following modifiers: -0.35 damage. -0.06 speed. -0.06 shot speed. +5% chance to fire a poison tear. When using for the 6th time, Death Cap is destroyed, fully heals all of Isaac's Red Heart containers and File:UI Bone Heart.png Bone Hearts, and grants the following modifiers: +2.75 damage. 1.5× damage multiplier. +0.5 speed. +0.5 shot speed.
Pumpkin Mask		1	On use, grants 12 Soul Hearts but causes Isaac to take damage every 60 seconds. 1 second after taking damage from this effect, Isaac will fire a Brimstone beam.
Shattered Dice		1	On use, or when Shattered Dice is dropped, the item is destroyed and spawns a Shattered Shard and 3 coins. Passively rerolls picked up items, attempting to reroll them into items of higher item quality.
Bone Saw		1	On use, destroys all nearby Beggars and Shopkeepers, and spawns 2 orbital bone familiars from each one destroyed. Butchering Beggars has a 5% chance to drop a random item from the Bone Saw item pool.
Blazing Beak		1	Passively causes enemies to sometimes drop Cursed Trinkets on death. Cursed Trinkets are auto-smelted on pickup. On use, deals 1 damage to Isaac and sells every Cursed Trinket he owns.

Passive Items

Name	Icon	Weight	Description
Azazel's Horn		1	+1 Black Heart. Black Hearts will now trigger their mass room damage effect when only partially depleted by damage.
Bad Apple		1	+0.6 tears. 8% chance to fire a tear that converts all other tears in the room into bad apples which deal half damage.
Bucket of Blood		1	+3 Red Heart containers. Rerolls all of Isaac's health into a random assortment of Heart Containers, Soul Hearts and Black Hearts.
Chunk of Tofu		1	Cube of Meat-style progressive familiar. Replaces all items in Boss Rooms with more Chunk of Tofus.
Cracked Infamy		1	2.5% chance to trigger the Glowing Hourglass effect when taking damage. Each time Isaac takes damage and the effect does not trigger, the chance increases by an additional 2.5% up to a maximum of 20%. The effect cannot trigger when fighting a boss that grants a completion mark.
Effigy		1	When entering an uncleared room, grants a 15% chance to replace all enemies with Burning Effigies. Effigies are completely harmless and have no hitbox, but can be bombed for a chance to spawn a random wooden pickup.
Empiric		1	Transforms all pills into Horse Pills. Naturally spawned horse pills are converted into Whale Pills instead. Causes all pills to become permanently unidentified. Spawns a random horse pill after being picked up.
Eye of Balor		1	The enemy with the lowest percentage health, that is not at full health, will take 1.5x damage from all sources.
Guppy's Pride		1	Grants a shooting familiar on pickup and at the start of every new floor. The familiars' tear damage scales with Isaac's Damage.
Joyful		1	Grants a chance to gain a 2× damage multiplier for the room when taking damage. In the following room afterwards, grants a 0.85× damage multiplier. 35% chance for a Joy Pill to drop on room clear, alongside normal rewards.
Kapala		1	1.5x Damage Multiplier. Damage dealt to enemies is split evenly amongst all other enemies of the same Type and Variant.
Mark of Cain		1	After 10 seconds of being in a non-special room, all doors will open. Taking damage from an enemy deals 7x your Damage to them.
Salesman's Eye		1	Grants a random discount to items in the shop Discounts range from 0-4 coins.
Silver Charm		1	+2 Soul Hearts. On pickup, converts all Heart Containers into Soul Hearts at a 1:3 ratio. Will not convert more Heart Containers if Isaac's health bar has been completely filled.
Slick Spade		1	{{{description}}}
Glioma		1	+0.3 Tears. Grants a 15% chance to fire a concussive tear. Upon defeating the floor's boss, all regular cleared rooms become uncompleted and can be re-beaten for additional rewards.
Bootlicker		1	+1 empty Heart Container. +0.25 Damage permanently for each time Isaac takes damage between gaining the item and killing a floor boss. Prevents Isaac from picking up hearts of any type until a floor's boss is killed.
Heartbroker		1	+1 Gold Heart. +2 Broken Hearts. Broken Hearts can now be used to purchase Devil Deals.
Jet Feather		1	Angel Deals no longer vanish when another item is taken, but will cost health to purchase. Devil Deals no longer cost health to purchase, but will vanish if another item is taken.
Heart Rupture		1	Enemies have a chance to launch a heart pickup into the air upon dying. The chance scales with Luck, the enemy's maximum health and the current stage. Catching the heart will heal Isaac. Missing the heart will cause it to splatter on the ground and spawn playe-controlled creep.