| Arrow of Light (edit) |
Arrow of Light |
Arrow of Light.png |
No |
Ascend to boyhood |
- +0.5 shot speed.
- +0.25 tears.
- Increases knockback.
- Grants piercing in darkness.
|
|
3 |
offensive • summonable • tearsup |
|
| Axolotl (edit) |
Axolotl |
Axolotl.png |
No |
I amn just a litle creacher |
- Spawns a familiar that follows Isaac, shoots tears and block enemy projectiles.
- After blocking 3 projectiles, dies and leaves behind a corpse that constantly spawns File:Blue Fly.png Blue Flies.
- Regenerates after entering a room.
|
|
2 |
offensive • summonable • monstermanual • baby |
|
| Azazel's Horn (edit) |
Azazel's Horn |
Azazel's Horn.png |
No |
Zealous black hearts |
- +1 Black Heart.
- Black Hearts will now trigger their mass room damage effect when only partially depleted by damage.
|
|
3 |
summonable • devil |
|
| Baby's Breath (edit) |
Baby's Breath |
Babys Breath.png |
No |
Belittling death rattle |
- On death, enemies Baptismally downgrade other nearby enemies.
- Downgrading radius scales with the enemy's maximum health.
|
|
2 |
summonable |
|
| Bad Apple (edit) |
Bad Apple |
Bad Apple.png |
No |
It takes only one |
- +0.6 tears.
- 8% chance to fire a tear that converts all other tears in the room into bad apples which deal half damage.
|
|
2 |
offensive • summonable • tearsup |
|
| Bag of Seeds (edit) |
Bag of Seeds |
Bag of Seeds.png |
No |
Bountiful harvest |
- Periodically spawns Pullroot saplings around the room.
|
|
3 |
offensive • summonable |
|
| Bandage Binder (edit) |
Bandage Binder |
Bandage Binder.png |
No |
Please bind responsibly |
- +2 range.
- +0.4 damage.
- Spawns 1-3 bone orbitals when taking damage.
|
|
2 |
nolostbr • summonable |
|
| Baptismal Font (edit) |
Baptismal Font |
Baptismal Font.png |
Yes |
Redemptive flood |
- Converts enemies in the room into weaker versions of themselves based off of a pre-defined evolution-tree.
|
4 |
1 |
offensive • angel |
Defeat ??? as Icarus |
| Baptismal Shell (edit) |
Baptismal Shell |
Baptismal Shell.png |
No |
Born of water and spirit |
- Chance for tears to transform enemies into a weaker variant of themselves based on a pre-defined evolution tree.
|
|
2 |
offensive • summonable • angel |
|
| Bar of Soap (edit) |
Bar of Soap |
Bar of Soap.png |
No |
Wash away your impurities |
- +1 Heart Container.
- Grants a Soul Heart at the start of each floor.
|
|
2 |
nolostbr |
|
| Baron Fly (edit) |
Baron Fly |
Baron Fly.png |
No |
Can't swallow its pride |
- Orbital familiar that fires a barrage of tears at the closest enemy after blocking 5 projectiles.
|
|
2 |
summonable • monstermanual • fly |
|
| Bedbug (edit) |
Bedbug |
Bedbug.png |
No |
Sleep tight |
- Orbital familiar that remains stationary relative to Isaac.
- Briefly orbits around Isaac after blocking a projectile.
|
|
1 |
summonable • monstermanual • fly |
|
| Beeconomy (edit) |
50% Beeconomy |
Fifty Percent Beeconomy.png |
No |
A Bugulon special! |
- +30 coins.
- Will always cost 15 coins.
- Spawns 5 red Melitodes Bees upon pickup and when entering a new room.
- Red Melitodes Bees deal 2x as much damage as normal Melitodes Bees.
- Purchasing items reduces the amount of bees spawned when entering a new room by 1.
|
|
3 |
offensive • noeden |
|
| Beeconomy (edit) |
Beeconomy |
Beeconomy.png |
No |
Economic colony collapse |
- +30 coins.
- Will always cost 15 coins.
- Spawns 3 Melitodes Bees upon pickup and when entering a new room.
- This effect stops working after another item is purchased.
|
|
2 |
offensive • summonable |
|
| Bell Clapper (edit) |
Bell Clapper |
Bell Clapper.png |
No |
Damage up, it's a dull ringer |
- +0.3 Tears.
- +1.5 Damage.
- The damage bonus given by this item is multiplied by 0.9 for every tear fired in the same room.
- Damage bonus reductions are negated when entering a new room.
|
|
3 |
offensive • summonable • tearsup |
|
| Bell of Circe (edit) |
Bell of Circe |
Bell of Circe.png |
Yes |
It tolls for pigs |
- On use, transforms a random enemy into a Circe Swine.
- Has a chance, that inversely scales with the amount of enemies in the room, to transform Isaac instead.
- When transformed, Isaac receives an all stats down and the item becomes unusable until the next room.
|
unlimited |
2 |
|
|
| Black Box (edit) |
Black Box |
Black Box.png |
Yes |
What's inside? |
- +4 luck while held.
- Each use:
- −0.5 luck permanently.
- Chance to spawn an item, Black Heart, Card, or hostile Spiders based on luck.
|
3 |
3 |
offensive |
|
| Black Hammer (edit) |
Black Hammer |
Black Hammer.png |
Yes |
I'll be the judge of that |
- On use, replaces tears with random numbers from 1 to 9.
- Damage of the numbers scales from 0.33x to 2.66x on numbers 1-8, and is quintupled on 9.
- Each number has a different unique effect.
|
3 |
2 |
offensive |
|
| Blazing Beak (edit) |
Blazing Beak |
Blazing Beak.png |
Yes |
Burning for curses |
- Passively causes enemies to sometimes drop
 Cursed Trinkets on death.
- Cursed Trinkets are auto-smelted on pickup.
- On use, deals 1 damage to Isaac and sells every Cursed Trinket he owns.
|
12 |
3 |
nolostbr |
Defeat <span style="position:relative; bottom: 1.5px;>[[file:Delirium.png|24x24px|link=https://bindingofisaacrebirth.fandom.com/wiki/Delirium]]</span> [https://bindingofisaacrebirth.fandom.com/wiki/Delirium Delirium] as [[File:UI_CoopIcon_T_Mammon.png|24px|link=Tainted Mammon]] [[Tainted Mammon]] |
| Bleeding Heart (edit) |
Bleeding Heart |
Bleeding Heart.png |
No |
Charming exsanguination |
- +1 Heart Container.
- Chance to fire a pink tear that inflicts Charm.
- Charmed enemies now fire Isaac's tears in random directions.
- Charmed enemies now charm other nearby enemies on death.
- Charming radius scales with the enemy's maximum health.
|
|
3 |
offensive • summonable |
|
| Blood of Satan (edit) |
Blood of Satan |
Blood of Satan.png |
No |
The soul atones for blood |
|
|
1 |
devil |
Defeat <span style="position:relative; bottom: 1.5px;>[[file:Satan.png|24x24px|link=https://bindingofisaacrebirth.fandom.com/wiki/Satan]]</span> [https://bindingofisaacrebirth.fandom.com/wiki/Satan Satan] as [[File:UI_CoopIcon_Icarus.png|24px|link=Icarus]] [[Icarus]] |
| Bob's Heart (edit) |
Bob's Heart |
Bobs Heart.png |
No |
Volatile friend |
- Grants two trailing familiars.
- Bob's Intestine: Trails closer to Isaac and inflicts poison to enemies it comes into contact with.
- Bob's Heart: Trails further from Isaac and explodes on contact with enemies.
|
|
0 |
uniquefamiliar • offensive • dead • bob |
|
| Bone Saw (edit) |
Bone Saw |
Bone Saw.png |
Yes |
Time to lose your medical license |
- On use, destroys all nearby Beggars and Shopkeepers, and spawns 2 orbital bone familiars from each one destroyed.
|
unlimited |
3 |
|
|
| Book of Genesis (edit) |
Book of Genesis |
Book of Genesis.png |
Yes |
And God saw that it was good |
- On use, grants a Black Heart.
- Passively doubles all damage taken.
|
3 |
2 |
nolostbr • book |
|
| Book of Mormon (edit) |
Book of Mormon |
Book of Mormon.png |
Yes |
Do you have a moment? |
- On use, Isaac holds the item above his head and creates an aura of fear around him.
|
2 |
1 |
book |
|
| Booster Shot (edit) |
Booster Shot |
Booster Shot.png |
No |
Compounding tears |
- -0.5 Damage.
- Grants piercing.
- The damage of Isaac's tears is increased by 1.5x for every enemy they pierce.
|
|
3 |
offensive • summonable • syringe |
|
| Bootlicker (edit) |
Bootlicker |
Bootlicker.png |
No |
It hurts so good |
- +1 empty Heart Container.
- +0.25 Damage permanently for each time Isaac takes damage between gaining the item and killing a floor boss.
- Prevents Isaac from picking up hearts of any type until a floor's boss is killed.
|
|
2 |
nolostbr |
|
| Bottled Fairy (edit) |
Bottled Fairy |
Bottled Fairy.png |
Yes |
Let your wounds heal |
- On use, heals Isaac to full.
- Will be used automatically, when Isaac is about to take fatal damage.
|
one time |
3 |
nolostbr |
|
| Brownie (edit) |
Brownie |
Brownie.png |
No |
Damage up, your bowels rumble |
- +1.5 Damage.
- While in uncleared rooms, Isaac will occasionally summon a friendly Corn Mine and leave a trail of brown, slippery creep for a few seconds.
|
|
2 |
offensive • summonable • poop |
|
| Brunch (edit) |
Brunch |
Brunch.png |
No |
HP up |
|
|
2 |
nolostbr • summonable • food |
|
| Bucket of Blood (edit) |
Bucket of Blood |
Bucket of Blood.png |
No |
Health up, mixed blood |
- +3
 Red Heart containers.
- Rerolls all of Isaac's health into a random assortment of Heart Containers, Soul Hearts and Black Hearts.
|
|
2 |
nolostbr • nokeeper |
|
| Bygone Arm (edit) |
Bygone Arm |
Bygone Arm.png |
Yes |
Feedbacker |
- On use, swings an arm, in a similar fashion to Forgotten's bone club.
- The arm can reflect enemy projectiles and, with tighter timing, boost Isaac's own tears.
- Reflected projectiles and boosted tears explode on contact with enemies or obstacles.
- Can be used from any item slot by pressing the button tied to consuming cards and pills, so long as Isaac has no consumable that would otherwise be used.
|
1.5s |
3 |
offensive |
|
| Cactus (edit) |
Cactus |
Cactus.png |
No |
Peashy keen |
- Spawns a stationary familiar in a random position each room that deals contact damage to enemies.
- Blocks Isaac's tears and enemy projectiles; after blocking 5 shots in total it bursts into a small shower of tears and a ring of tacs.
- After bursting, regenerates after a few seconds.
|
|
1 |
offensive • summonable • monstermanual |
|
| Caduceus (edit) |
Caduceus |
Caduceus.png |
No |
Equalized healing |
- Transforms all full Red Heart and full Soul Heart pickups into Blended Hearts.
|
|
4 |
nolostbr • summonable |
|
| Carapace (edit) |
Carapace |
Carapace.png |
No |
Exoskeleton |
- Upon entering an uncleared room, Isaac gains a shell that gives the following:
- +1 flat damage.
- 0.75× speed multiplier.
- Negates the first instance of damage, destroying the shell and removing the stat modifiers.
|
|
4 |
nolostbr • summonable |
|
| Cataract (edit) |
Cataract |
Cataract.png |
No |
Cloudy vision |
- Increases tear size.
- Tears decelerate until they stop moving entirely.
- Tears remain in the air for a longer time.
|
|
2 |
summonable |
|
| Celestial Berry (edit) |
Celestial Berry |
Celestial Berry.png |
No |
Feather away |
- When entering an uncleared room for the first time, a winged berry will appear in a random position.
- Picking up the berry grants:
- +1 Damage, +0.5 Tears, and flight for the room.
- +0.05 Luck permanently.
- The berry will fly away if not picked up within 3 seconds.
|
|
3 |
offensive • summonable |
|
| Chastity Belt (edit) |
Chastity Belt |
Chastity Belt.png |
No |
Your body is a temple |
- +2 Damage.
- The given damage up will be decreased depending on how many keys you have.
- Key pickups disappear after leaving and re-entering the room they are located in.
|
|
2 |
offensive • summonable |
|
| Chimerism (edit) |
Chimerism |
Chimerism.png |
No |
I art I |
- +2 Heart Containers.
- +2 Damage.
- 2 bombs are placed at once for no extra cost.
|
|
3 |
offensive • summonable |
|
| Cholera (edit) |
Cholera |
Cholera.png |
No |
Crappy aim |
- +1 Luck.
- Chance to fire a brown tear that transforms enemies into Poop.
- Chance scales with Luck.
- Brown tears are fired at slightly wonky angles.
|
|
3 |
summonable • poop |
|
| Chunk of Tofu (edit) |
Chunk of Tofu |
Chunk of Tofu.png |
No |
Packed with phytoestrogens |
- Cube of Meat-style progressive familiar.
- Replaces all items in Boss Rooms with more Chunk of Tofus.
|
|
2 |
|
|
| Coil (edit) |
Coil |
Coil.png |
No |
Coiling orbital |
- Orbital familiar that briefly moves further away from Isaac after blocking a projectile.
- After blocking a shot, it slowly difts back towards Isaac.
|
|
2 |
summonable • monstermanual |
|
| Coinflip (edit) |
Coinflip |
Coinflip.png |
Yes |
Ricoshot |
- +3 coins.
- On use, consumes a coin, 1 charge notch and spawns a spinning coin.
- The spinning coin ricochets Isaac's tears into enemies, multiplying their damage by 1.5.
- Picking up the coin before it disappears grants 1 charge notch back.
|
coinflip |
3 |
offensive |
|
| Communion (edit) |
Communion |
Communion.png |
Yes |
Excommunicated tears |
- On use, reverses the trajectory of all enemy projectiles and transforms them into friendly homing tears.
- Additionally, all Troll Bombs are transformed into regular bombs that home towards enemies.
|
6s |
1 |
angel |
|
| Conjunctivitis (edit) |
Conjunctivitis |
Conjunctivitis.png |
No |
Eye sack |
- -1 Fire Delay.
- Isaac's tears now leave puddles of slowing creep.
|
|
2 |
nolostbr • summonable • tearsup |
|
| Cootie (edit) |
Cootie |
Cootie.png |
No |
Ew, gross! |
- Familiar that charms the non-boss enemy in the room with the highest health.
|
|
3 |
summonable • monstermanual |
|
| Corpse Flower (edit) |
Corpse Flower |
Corpse Flower.png |
No |
Gangrenous tears |
- Spawns a Rotten Heart on pickup.
- Chance to fire a green tear that inflicts a long-lasting but weak Poison.
- Poisoned enemies now periodically spawn a Blue Fly.
- These Blue Flies will not target the enemy that spawned them.
|
|
3 |
offensive • summonable |
|
| Cracked Infamy (edit) |
Cracked Infamy |
Cracked Infamy.png |
No |
Damage reduction... ? |
- 2.5% chance to trigger the
 Glowing Hourglass effect when taking damage.
- Each time Isaac takes damage and the effect does not trigger, the chance increases by an additional 2.5% up to a maximum of 20%.
- The effect cannot trigger when fighting a boss that grants a completion mark.
|
|
1 |
summonable |
|
| Cyst (edit) |
Cyst |
Cyst.png |
No |
First strike! |
- 10x Damage Multiplier until after the first time Isaac fires in each room.
- If 5 seconds pass Isaac will lose the damage boost automatically.
|
|
3 |
offensive • summonable |
|
| Dead Lung (edit) |
Dead Lung |
Dead Lung.png |
No |
Coughing up blood |
- +1 Black Heart.
- Isaac creates a pool of red creep when taking damage.
|
|
1 |
dead |
|
| Death Cap (edit) |
Death Cap |
All Death Caps.gif |
Yes |
Strength through mithridatism |
- When using for the first 5 times, Isaac takes damage and permanently gains the following modifiers:
- When using for the 6th time, Death Cap is destroyed, fully heals all of Isaac's Red Heart containers and File:UI Bone Heart.png Bone Hearts, and grants the following modifiers:
- +2.75 damage.
- 1.5× damage multiplier.
- +0.5 speed.
- +0.5 shot speed.
|
4 |
3 |
mushroom |
|
| Defibrillator (edit) |
Defibrillator |
Defibrillator.png |
No |
Starting to see black |
- 1.5x Damage Multiplier in alternating rooms.
|
|
2 |
offensive • summonable |
|
| Derelict Anchor (edit) |
Derelict Anchor |
Derelict Anchor.png |
No |
Shipwrecked |
- Enemies are bound to an anchor that restricts their movement speed.
- The anchor can break rocks it's dragged through.
- The anchor will be destroyed if its host becomes intangible or it is dragged over a pit.
|
|
3 |
summonable |
|
| Devil's Tooth (edit) |
Devil's Tooth |
Devils Tooth.png |
No |
Exsanguinating strength |
- Grants a chance to fire a tear that upgrades the hit enemy into a stronger version of itself.
- If the enemy is successfully transformed, its current health is halved.
- Chance scales with Luck.
|
|
2 |
offensive • summonable • mushroom |
|
| Dominicus (edit) |
Dominicus |
Dominicus.png |
No |
Long-lost natal sun |
- Grants 3 orbital familiars that cycle through 9 variants in a set order.
- The familiars are launched in the direction Isaac is firing when they align with his line-of-sight, each with a unique effect.
- Dominicus familiars break after hitting a wall and will be replaced with the next variant after a couple of seconds.
|
|
3 |
offensive • uniquefamiliar |
|
| Dowsing Rod (edit) |
Dowsing Rod |
Dowsing Rod.png |
Yes |
Water witching |
- On use, causes Isaac to hold the item above his head. While held, raining tears that leave a puddle of creep, and the occasional File:Crack the Sky.png Crack the Sky beam of light, will begin to strike random places in the room.
- The longer the item is held, the more frequently the tears and beams of light will be summoned, reaching their maximum intensity after 15 seconds.
- The item can be held between rooms, maintaining the strength of the effect.
|
2 |
2 |
offensive |
|
| Effigy (edit) |
Effigy |
Effigy.png |
No |
See them burn |
- When entering an uncleared room, grants a 15% chance to replace all enemies with Burning Effigies.
- Effigies are completely harmless and have no hitbox, but can be bombed for a chance to spawn a random wooden pickup.
|
|
3 |
summonable |
|
| Empiric (edit) |
Empiric |
Empiric.png |
No |
Quack medicine |
- Transforms all pills into Horse Pills.
- Naturally spawned horse pills are converted into
 Whale Pills instead.
- Causes all pills to become permanently unidentified.
- Spawns a random horse pill after being picked up.
|
|
3 |
summonable |
|
| Eternal Bombs (edit) |
Eternal Bombs |
Eternal Bombs.png |
No |
Cast the beast into a lake of fire |
- +5 Bombs.
- Bombs deal double damage to bosses.
|
|
3 |
offensive • summonable |
|
| Eve's Nail Polish (edit) |
Eve's Nail Polish |
Eves Nail Polish.png |
No |
Every shot counts |
- Landing a tear on an enemy reduces the time until Isaac can fire his next shot.
|
|
2 |
offensive • summonable |
|
| Everlasting Pill (edit) |
Everlasting Pill |
Everlasting Pill.png |
Yes |
Stat-alteration free |
- On use, activates a random pill effect from a set list, which includes all pill effects that do not affect Isaac's stats or health.
|
5s |
1 |
|
|
| Everlasting Pill (edit) |
Neverlasting Pill |
Neverlasting Pill.png |
Yes |
Stat-alteration packed! |
- Simultaneously consume 6 random stat-altering pills.
|
one time |
2 |
|
|
| Eye of Balor (edit) |
Eye of Balor |
Eye of Balor.png |
No |
Dominate and destroy |
- The enemy with the lowest percentage health, that is not at full health, will take 1.5x damage from all sources.
|
|
3 |
offensive • summonable • devil |
|
| F.O.P. (edit) |
F.O.P. |
FOP.png |
No |
Unbreakable |
- Spawns a Bone Heart on pickup.
- If Isaac would take fatal damage, it is prevented and all of his Heart Containers are replaced with empty Bone Hearts.
- This can be repeated infinitely so long as Isaac has Heart Containers to convert.
|
|
3 |
summonable |
|
| False Idol (edit) |
False Idol |
False Idol.png |
Yes |
An untrue faith |
- On use, grants a familiar that passively grants +10.9 luck.
- The familiar is removed after leaving the room.
|
3 |
3 |
monstermanual |
|
| False Idol (edit) |
False Promise |
False Promise.png |
No |
Communication breakdown |
|
|
2 |
|
|
| Forbidden Fruit (edit) |
Forbidden Fruit |
Forbidden Fruit.png |
No |
Damage up? |
- 0.65x Damage Multiplier, then grants +5 flat Damage.
|
|
2 |
offensive • summonable • angel |
|
| Frail Fly (edit) |
Frail Fly |
Frail Fly.png |
No |
He's weak |
- Orbital familiar that deals heavy contact damage and blocks enemy projectiles, but dies after blocking 3 shots.
- Respawns when entering another room.
|
|
1 |
summonable • monstermanual • fly |
|
| Friend Folio (edit) |
Friend Folio |
Friend Folio.png |
No |
Rival chapter |
- Grants a random Retribution familiar that changes every room.
- May grant a Friend familiar unique to this item.
- Friend walks around the room targeting enemies like a level 4
 Cube of Meat.
- Friend periodically fires fire tears at her target.
|
|
2 |
summonable • book |
|
| Friendly Monster (edit) |
Friendly Monster |
Friendly Monster.png |
No |
Lost in orbit |
- Orbital famliar that orbits a random enemy in the room, while shooting spectral tears in the same direction as Isaac.
|
|
2 |
summonable • monstermanual |
|
| Fry's Paw (edit) |
Fry's Paw |
Frys Paw.png |
Yes |
Bone converter |
- On use, removes one filled Red Heart container, grants 2 empty Bone Hearts and creates a puddle of red creep underneath Isaac.
- Has no effect if Isaac has no filled Heart Containers.
|
unlimited |
1 |
nolostbr |
|
| Gacha-Go (edit) |
Gacha-Go |
Gacha Go.png |
Yes |
Pull on the go! |
- On use, consumes 5 coins and spawns one of the following:
|
unlimited |
1 |
|
|
| Glioma (edit) |
Glioma |
Glioma.png |
No |
Say that again |
- +0.3 Tears.
- Grants a 15% chance to fire a concussive tear.
- Upon defeating the floor's boss, all regular cleared rooms become uncompleted and can be re-beaten for additional rewards.
|
|
3 |
offensive • summonable • tearsup • nogreed |
|
| Gloriosa (edit) |
Gloriosa |
Gloriosa.png |
No |
Blazing Tears |
- 0.75× tear rate multiplier.
- Tears travel in an arc and leave behind a fire jet when colliding.
- Tears inflict burn to enemies on direct hits.
|
|
3 |
offensive • summonable |
|
| Guppy's Pride (edit) |
Guppy's Pride |
Guppys Pride.png |
No |
What's up with that? |
- Grants a shooting familiar on pickup and at the start of every new floor.
- The familiars' tear damage scales with Isaac's Damage.
|
|
2 |
offensive • summonable • guppy |
|
| Ham (edit) |
Ham |
Ham.png |
No |
Long pork |
- +1 Red Heart container.
- +2 Black Hearts.
- +0.75 damage.
- +3.5 range.
|
|
3 |
offensive |
|
| Heart Rupture (edit) |
Heart Rupture |
Heart Rupture.png |
No |
Bursting hearts! |
- Enemies have a chance to launch a heart pickup into the air upon dying.
- The chance scales with Luck, the enemy's maximum health and the current stage.
- Catching the heart will heal Isaac.
- Missing the heart will cause it to splatter on the ground and spawn playe-controlled creep.
|
|
2 |
nolostbr • summonable |
|
| Heart Shaped Balloon (edit) |
Heart Shaped Balloon |
Heart Shaped Balloon.png |
No |
Pretty balloon |
- Grants a trailing balloon familiar.
- For every cleared room, the familiar will change colors to resemble a specific heart pickup.
- Taking damage pops the balloon and spawns the respective heart on the ground.
- The balloon will regenerate back to its first form upon entering the next room.
- If the balloon resembles an Eternal Heart, it will pop automatically after clearing another room.
|
|
4 |
nolostbr • summonable |
|
| Heartbroker (edit) |
Heartbroker |
Heartbroker.png |
No |
Blood money |
- +1 Gold Heart.
- +2 Broken Hearts.
- Broken Hearts can now be used to purchase Devil Deals.
|
|
2 |
nolostbr • summonable |
|
| Heel Spur (edit) |
Heel Spur |
Heel Spur.png |
No |
Speed = DMG |
- +1 Bone Heart.
- Applies a Damage Multiplier that scales with how fast Isaac is moving.
|
|
3 |
offensive • summonable |
|
| Hemorrhoid (edit) |
Hemorrhoid |
Hemorrhoid.png |
No |
Charged blood blast |
- Charges up a
 Monstro's Lung style tear volley while firing.
- Releasing the firing buttons fires the tear volley opposite to the direction Isaac is moving.
- Taking damage spawns a Red Poop.
|
|
2 |
offensive • summonable |
|
| Hundred Dollar Steak (edit) |
Hundred Dollar Steak |
Hundred Dollar Steak.png |
No |
Don't swallow in one bite |
|
|
1 |
nolostbr • summonable |
|
| Hyperopia (edit) |
Hyperopia |
Hyperopia.png |
No |
Hyper tears |
- +0.3 Tears.
- Tears accelerate as they travel, gaining piercing once they reach high enough speed.
|
|
2 |
offensive • summonable • tearsup |
|
| Impact Wax (edit) |
Impact Wax |
Impact Wax.png |
No |
Did you say something? |
- +0.5 Damage.
- While shooting, short-ranged tears that leave puddles of slowing creep and deal 0.75x of Isaac's damage are fired from the sides.
|
|
3 |
offensive • summonable |
|
| Jet Feather (edit) |
Jet Feather |
Jet Feather.png |
No |
Fall |
- Angel Deals no longer vanish when another item is taken, but will cost health to purchase.
- Devil Deals no longer cost health to purchase, but will vanish if another item is taken.
|
|
2 |
summonable • devil |
|
| Joyful (edit) |
Joyful |
Joyful.png |
No |
You feel nothing |
- Grants a chance to gain a 2× damage multiplier for the room when taking damage.
- In the following room afterwards, grants a 0.85× damage multiplier.
- 35% chance for a Joy Pill to drop on room clear, alongside normal rewards.
|
|
2 |
offensive • summonable |
|
| Kapala (edit) |
Kapala |
Kapala.png |
No |
Shared blood |
- 1.5x Damage Multiplier.
- Damage dealt to enemies is split evenly amongst all other enemies of the same Type and Variant.
|
|
4 |
offensive • summonable • devil |
|
| Kompu Gacha (edit) |
Kompu Gacha |
Kompu Gacha.png |
No |
Capitalism and its swinest |
- Spawns a random Capsule, then, for every 5 coins Isaac currently holds:
- Spawns another random Capsule.
- Removes 5 coins.
- Capped at spawning 10 Capules.
|
|
2 |
|
|
| Laughing Gas (edit) |
Laughing Gas |
Laughing Gas.png |
No |
Winners don't use drugs |
- +0.3 Shot Speed.
- -1 Fire Delay.
|
|
2 |
offensive • summonable • tearsup |
|
| Lemon Head (edit) |
Lemon Head |
Lemon Head.png |
No |
Tears up, pucker up |
- +0.8 Tears.
- +2.5 Range.
- Reduces tear size.
|
|
2 |
offensive • summonable • tearsup |
|
| Lent (edit) |
Lent |
Lent.png |
No |
Abstainence... |
- Not picking up hearts for a floor will grant full health and +0.5 Damage at the start of the next floor.
|
|
1 |
offensive • summonable |
|
| Lifeblood Syringe (edit) |
Lifeblood Syringe |
Lifeblood Syringe.png |
Yes |
Vital injection |
- Starts with 4 charges out of 8.
- Can be recharged only by killing Lifeseed Spirits that sometimes spawn when killing enemies.
- On use, grants 2 Soul Hearts.
|
8 |
3 |
nolostbr • nokeeper • syringe |
|
| Lily (edit) |
Lily |
Lily.png |
Yes |
No need for peace |
- On use, explodes any enemies with less than 1/3 of their maximum health remaining.
- Does not work on bosses.
- Valid enemies will faintly glow red.
|
12s |
1 |
offensive |
|
| Mad Onion (edit) |
Mad Onion |
Mad Onion.png |
No |
So pungent, so divine |
- Grants a chance to fire a tear that deals 3.2x damage but possesses no tear effects.
|
|
2 |
offensive • summonable |
|
| Mark of Cain (edit) |
Mark of Cain |
Mark of Cain.png |
No |
Wear it with shame |
- After 10 seconds of being in a non-special room, all doors will open.
- Taking damage from an enemy deals 7x your Damage to them.
|
|
2 |
nolostbr • summonable • devil |
|
| Meat Grinder (edit) |
Meat Grinder |
Meat Grinder.png |
Yes |
A taste for oneself |
- On use, deals damage to Isaac and spawns a Swine Beggar.
|
6 |
3 |
nolostbr |
|
| Melatonin (edit) |
Melatonin |
Melatonin.png |
Yes |
Zzz... |
- On use, paralyses Isaac for 2 seconds and grants the following effects for the current room:
- +0.75 tears.
- Hitting enemies with tears will gradually slow them down. If an enemy is hit with enough tears, the enemy will briefly freeze in place.
- Sleeping in a bed grants a Red Heart container.
|
1 |
2 |
offensive |
|
| Melitodes (edit) |
Melitodes |
Melitodes.png |
No |
Honeyed one |
- Grants a chance to fire a tear that creates a Melitodes Bee when hitting an enemy.
- The chance scales with Luck.
|
|
2 |
offensive • summonable |
|
| Milk of Baphomet (edit) |
Milk of Baphomet |
Milk of Baphomet.png |
No |
HP up, random on-hit effects |
- +1 Heart Container.
- Taking damage triggers a random on-damage effect.
|
|
2 |
nolostbr • summonable |
|
| Milk Teeth (edit) |
Milk Teeth |
Milk Teeth.png |
No |
Delayed splinter shot |
- 0.5x tear rate multiplier.
- Tears split into a spread of 5 blood shots after traveling far enough from Isaac.
|
|
3 |
offensive • summonable |
|
